Your choice of tire depends on what characteristics are most important to you. Do you want maximum performance? Or do you want a smooth quiet ride? Do you drive in wet weather or snow? Do you want a summer-only tire, or an all-season?
Others will certainly chime in with their opinions. For me, I wanted a smooth quiet ride, so I chose Bridgestone Turanza LS tires. They come in a variety of sizes and speed ratings. They are also highly rated by customers on the Tirerack website. After about 5000 miles, I am very happy with them.
As for the alignment, I always get a 4-wheel alignment when I get new tires. Some say the LS doesn't need it, but I think it is cheap insurance. I don't trust 3rd party tire shops to align my car correctly, so I have the dealer do it. It usually runs about $70 for a 4-wheel alignment.