Caliper location on the knuckle has more to do with cooling then anything else. Certain positions will tool better but pick up more trash/water/etc. Having the caliper slightly to the front of the center line of the knuckle on top will get it some airflow and help keep trash out. Having it trailing the centerline (to the back) of the knuckle will give more cooling but pick up more trash. No one puts them on the bottom of the knuckle since it's impractical (there's a ball joint down there and all) and you'd never get trash out of them. Another consideration on really big brakes, like 6 piston calipers, is where you can physically put them without hitting other suspension components.
Other then that I don't think you get anything from location on the spindle. Unsprung weight is unsprung weight. They don't weigh enough to cause any deflection in the suspension geometry.
Other then that I don't think you get anything from location on the spindle. Unsprung weight is unsprung weight. They don't weigh enough to cause any deflection in the suspension geometry.