It's usually the plug boot that starts leaking voltage and creates a misfire. In my experience is that most misfires can be repaired long term by changing all the the boots and spark plugs as a set. The boots are made by AC and cost about $6/ea. My '03 LS8 has 210,000 miles, and I haven't bought a coil in the last 110,000 miles, but I have changed all the the boots and spark plugs 3 times in the last 110,000 miles.
There's history of PCM's failing fairly often on LS. I'm sure this is related to misfires. Deal with them as soon as possible!